Title : Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.

Pub. Date : 2021 Nov 1

PMID : 34720086






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 in colorectal cancer (CRC) cells, which enhanced PHGDH activity by recruiting a chaperone protein, DnaJ homolog subfamily A member 1, to promote its tetrameric formation, thereby increasing the levels of serine, glycine, and S-adenosylmethionine (SAM). Glycine DnaJ heat shock protein family (Hsp40) member A1 Homo sapiens