CPRiL

Protein Name	DnaJ heat shock protein family (Hsp40) member A1
Organism	Homo sapiens
Gene ID	3301
Gene Symbol	DNAJA1
UniProt	P31689 (DNJA1_HUMAN), B7Z5C0 (B7Z5C0_HUMAN)
Relationships	Total Number of functionally related compound(s) : 32 Total Number of Articles : 35
Description	DnaJ heat shock protein family (Hsp40) member A1
Gene Summary	This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]
synonyms	dnaJ homolog subfamily A member 1 DnaJ (Hsp40) homolog, subfamily A, member 1 dnaJ protein homolog 2 heat shock 40 kDa protein 4 heat shock protein J2 heat shock protein, DNAJ-like 2 human DnaJ protein 2 neural precursor cell expressed, developmentally down-regulated 7 DJ-2 DjA1 HDJ2 HSDJ HSJ-2 HSJ2 HSPF4 NEDD7 hDJ-2 Click to show/hide the synonyms
Properties