Protein Name DnaJ heat shock protein family (Hsp40) member A1
Organism Homo sapiens
Gene ID 3301
Gene Symbol


UniProt P31689 (DNJA1_HUMAN), B7Z5C0 (B7Z5C0_HUMAN)
Relationships Total Number of functionally related compound(s) : 32
Total Number of Articles : 35

DnaJ heat shock protein family (Hsp40) member A1

Gene Summary

This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

  • dnaJ homolog subfamily A member 1
  • DnaJ (Hsp40) homolog, subfamily A, member 1
  • dnaJ protein homolog 2
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