Title : CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1.

Pub. Date : 2021 Oct 27

PMID : 34707185






2 Functional Relationships(s)
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1 Indeed, the Mcl-1-specific inhibitor S63845 restored apoptosis by disrupting the interaction of Mcl-1 with Bim and Bak and significantly increased AraC toxicity in CD157-high but not in CD157-low AML cells. S63845 MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 Indeed, the Mcl-1-specific inhibitor S63845 restored apoptosis by disrupting the interaction of Mcl-1 with Bim and Bak and significantly increased AraC toxicity in CD157-high but not in CD157-low AML cells. S63845 MCL1 apoptosis regulator, BCL2 family member Homo sapiens