Title : PPARĪ² down-regulation is involved in high glucose-induced endothelial injury via acceleration of nitrative stress.

Pub. Date : 2022 Jan

PMID : 34699845






2 Functional Relationships(s)
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1 A high glucose level significantly decreased the expression of PPARbeta and endothelial nitric oxide synthase (eNOS) at the mRNA and protein levels, and reduced the concentration of nitric oxide (NO), which occurred in parallel with an increase in the expression of inducible nitric oxide synthase (iNOS) and 3-nitrotyrosine. Glucose nitric oxide synthase 2 Rattus norvegicus
2 A high glucose level significantly decreased the expression of PPARbeta and endothelial nitric oxide synthase (eNOS) at the mRNA and protein levels, and reduced the concentration of nitric oxide (NO), which occurred in parallel with an increase in the expression of inducible nitric oxide synthase (iNOS) and 3-nitrotyrosine. Glucose nitric oxide synthase 2 Rattus norvegicus