Pub. Date : 2021 Sep
PMID : 34697748
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Andrographolide Induces Apoptosis in Gastric Cancer Cells through Reactivation of p53 and Inhibition of Mdm-2. | andrographolide | tumor protein p53 | Homo sapiens |
| 2 | Effect of andrographolide on p53 activity was ascertained by using a p53 activator (RITA) which showed synergistic inhibition of cell proliferation. | andrographolide | tumor protein p53 | Homo sapiens |
| 3 | While andrographolide when used in combination with a p53 inhibitor (pifithrin-alpha) showed potent restriction over its response. | andrographolide | tumor protein p53 | Homo sapiens |
| 4 | Andrographolide activated the expression of p53 protein and gene and downregulated the levels of Mdm-2 (negative regulator of p53). | andrographolide | tumor protein p53 | Homo sapiens |
| 5 | Andrographolide activated the expression of p53 protein and gene and downregulated the levels of Mdm-2 (negative regulator of p53). | andrographolide | tumor protein p53 | Homo sapiens |
| 6 | Andrographolide inhibited the colony formation abilities in SGC7901 in a p53-dependent manner followed by induction of mitochondrial intrinsic apoptosis through activation of caspases-9 and -3, cleavage of PARP, and inhibition of pro-apoptotic Bcl-2. | andrographolide | tumor protein p53 | Homo sapiens |
| 7 | Andrographolide induced p53 mediated apoptosis in gastric carcinoma cells which adds to a novel approach in anticancer therapies. | andrographolide | tumor protein p53 | Homo sapiens |