Title : Sorafenib treatment of metastatic melanoma with c-Kit aberration reduces tumor growth and promotes survival.

Pub. Date : 2021 Dec

PMID : 34691254






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Sorafenib is a tyrosine kinase inhibitor, whose targets include c-Kit, platelet derived growth factor receptor (PDGFR), VEGFR and RAF. Sorafenib kinase insert domain receptor Homo sapiens
2 Mechanistically, sorafenib inhibited c-Kit, PDGFR, VEGFR, B-Raf and c-Raf phosphorylation both in vitro and in vivo. Sorafenib kinase insert domain receptor Homo sapiens