Pub. Date : 2022 Jan 1
PMID : 34687791
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of IL-6Ralpha by ATF3 enhances IL-6 mediated sorafenib and regorafenib resistance in hepatocellular carcinoma. | Sorafenib | interleukin 6 | Homo sapiens |
| 2 | Depletion of IL-6Ralpha abolished IL-6 induced STAT3 phosphorylation at 705th tyrosine and tumor growth of HCC cells under sorafenib treatment. | Sorafenib | interleukin 6 | Homo sapiens |
| 3 | Depletion of ATF3 or its upstream transcription factor, ATF4, attenuated IL-6Ralpha induction and IL-6 mediated sorafenib resistance. | Sorafenib | interleukin 6 | Homo sapiens |