Pub. Date : 2021 Oct 22
PMID : 34686655
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Positive feedback between ROS and cis-axis of PIASxalpha/p38alpha-SUMOylation/MK2 facilitates gastric cancer metastasis. | Reactive Oxygen Species | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | MAPK/p38 is an important mammalian signaling cascade that responds to a variety of intracellular or extracellular stimuli, such as reactive oxygen species (ROS), and participates in numerous physiological and pathological processes. | Reactive Oxygen Species | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | MAPK/p38 is an important mammalian signaling cascade that responds to a variety of intracellular or extracellular stimuli, such as reactive oxygen species (ROS), and participates in numerous physiological and pathological processes. | Reactive Oxygen Species | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | Importantly, we determine that p38alpha-SUMOylation functions as an authentic sensor and accelerator of reactive oxygen species generation via interaction with and activation of MK2 in the nucleus, and the ROS accumulation, in turn, promotes the SUMOylation of p38alpha by stabilizing the PIASxalpha protein. | Reactive Oxygen Species | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | Importantly, we determine that p38alpha-SUMOylation functions as an authentic sensor and accelerator of reactive oxygen species generation via interaction with and activation of MK2 in the nucleus, and the ROS accumulation, in turn, promotes the SUMOylation of p38alpha by stabilizing the PIASxalpha protein. | Reactive Oxygen Species | mitogen-activated protein kinase 14 | Homo sapiens |
| 6 | Importantly, we determine that p38alpha-SUMOylation functions as an authentic sensor and accelerator of reactive oxygen species generation via interaction with and activation of MK2 in the nucleus, and the ROS accumulation, in turn, promotes the SUMOylation of p38alpha by stabilizing the PIASxalpha protein. | Reactive Oxygen Species | mitogen-activated protein kinase 14 | Homo sapiens |