Title : Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association.

Pub. Date : 2021 Oct 9

PMID : 34685684






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, using biophysical, biochemical, pharmaceutical, and genetic approaches, we show that apoptotic cells induced the Orai1-STIM1 interaction, leading to store-operated calcium entry (SOCE) in phagocytes through the Mertk-phospholipase C (PLC) gamma1-inositol 1,4,5-triphosphate receptor (IP3R) axis. Calcium inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens