Pub. Date : 2021
PMID : 34671194
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment with U18666A reduced the cellular cholesterol level and blocked the anti-apoptotic function of IGF-1 by impairing the formation of caveolae and the localization of IGF-1 receptor in caveolae of the PC12 cells. | 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one | insulin-like growth factor 1 | Rattus norvegicus |
| 2 | Furthermore, the phosphorylation levels of IGF-1 receptor, insulin receptor substrate (IRS), Akt, and Bad in response to IGF-1 were all found to decrease in the U18666A-treated cells. | 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one | insulin-like growth factor 1 | Rattus norvegicus |
| 3 | Rats treated with U18666A via intracerebral injection also exhibited a significant decrease in the cholesterol level and impaired activities of IGF-1-related signaling proteins in the hippocampus region. | 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one | insulin-like growth factor 1 | Rattus norvegicus |