Title : A High-Content Screen for C/EBPα Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma.

Pub. Date : 2022 Jan 1

PMID : 34667024






2 Functional Relationships(s)
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1 SN-38 had the lowest IC50 (approximately 10 nM), and its pro-apoptotic effects were countered by knockdown of CEBPA but not of TP53 Irinotecan significantly inhibited tumor growth at well tolerated doses, induced nuclear expression of C/EBPalpha, and inhibited HIF1a expression in DDLS patient-derived and cancer cell line xenograft models. Irinotecan hypoxia inducible factor 1 subunit alpha Homo sapiens
2 SN-38 had the lowest IC50 (approximately 10 nM), and its pro-apoptotic effects were countered by knockdown of CEBPA but not of TP53 Irinotecan significantly inhibited tumor growth at well tolerated doses, induced nuclear expression of C/EBPalpha, and inhibited HIF1a expression in DDLS patient-derived and cancer cell line xenograft models. Irinotecan hypoxia inducible factor 1 subunit alpha Homo sapiens