Pub. Date : 2022 Jan 1
PMID : 34667024
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | SN-38 had the lowest IC50 (approximately 10 nM), and its pro-apoptotic effects were countered by knockdown of CEBPA but not of TP53 Irinotecan significantly inhibited tumor growth at well tolerated doses, induced nuclear expression of C/EBPalpha, and inhibited HIF1a expression in DDLS patient-derived and cancer cell line xenograft models. | Irinotecan | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
2 | SN-38 had the lowest IC50 (approximately 10 nM), and its pro-apoptotic effects were countered by knockdown of CEBPA but not of TP53 Irinotecan significantly inhibited tumor growth at well tolerated doses, induced nuclear expression of C/EBPalpha, and inhibited HIF1a expression in DDLS patient-derived and cancer cell line xenograft models. | Irinotecan | hypoxia inducible factor 1 subunit alpha | Homo sapiens |