Title : Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions.

Pub. Date : 2021 Oct

PMID : 34664206






1 Functional Relationships(s)
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1 The processes implemented to describe the rosuvastatin pharmacokinetics and DDIs are active uptake by OATP2B1, OATP1B1/OATP1B3 and OAT3, active efflux by BCRP and Pgp, metabolism by CYP2C9 and passive glomerular filtration. Rosuvastatin Calcium cytochrome P450 family 2 subfamily C member 9 Homo sapiens