Title : Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1.

Pub. Date : 2021 Nov 2

PMID : 34662099






1 Functional Relationships(s)
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1 The observed switch in substrate specificity of the enzyme is consistent with this result if the hydrogen bonding to the proximal peroxo oxygen is necessary for a proposed nucleophilic peroxoanion-mediated mechanism for CYP17A1 in carbon-carbon bond scission. Oxygen cytochrome P450 family 17 subfamily A member 1 Homo sapiens