Title : DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-κB Pathway.

Pub. Date : 2021

PMID : 34650664






1 Functional Relationships(s)
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1 Together, these results suggest that DL0410 exerts neuroprotective effects against hippocampus and cortex injury induced by D-galactose, and the possible mechanisms include antioxidative stress, antineuroinflammation, improving synaptic plasticity, and maintaining BBB integrity, which is mediated by the TLR4/MyD88/NF-kappaB signaling pathway inhibition. Galactose nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus