Title : FV-429 enhances the efficacy of paclitaxel in NSCLC by reprogramming HIF-1α-modulated FattyAcid metabolism.

Pub. Date : 2021 Dec 1

PMID : 34648812






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The HIF-1alpha protein upregulated the expression of adipose differentiation-related protein (ADRP), fatty acid synthase (FASN), and sterol regulatory element binding protein 1(SREBP1), while simultaneously downregulating carnitine palmitoyltransferase 1 (CPT1), thereby leading to a more pronounced uptake of lipids and reduced oxidation of fatty acids. Fatty Acids carnitine palmitoyltransferase 1A Homo sapiens
2 The HIF-1alpha protein upregulated the expression of adipose differentiation-related protein (ADRP), fatty acid synthase (FASN), and sterol regulatory element binding protein 1(SREBP1), while simultaneously downregulating carnitine palmitoyltransferase 1 (CPT1), thereby leading to a more pronounced uptake of lipids and reduced oxidation of fatty acids. Fatty Acids carnitine palmitoyltransferase 1A Homo sapiens