Pub. Date : 2021 Dec 3
PMID : 34637964
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cluster of differentiation (CD) 38, a major enzyme for nicotinamide adenine dinucleotide (NAD+) degradation, plays a key role in inflammation. | NAD | CD38 antigen | Mus musculus |
| 2 | Cluster of differentiation (CD) 38, a major enzyme for nicotinamide adenine dinucleotide (NAD+) degradation, plays a key role in inflammation. | NAD | CD38 antigen | Mus musculus |
| 3 | However, CD38 inhibition by 78c elevated intracellular NAD+ levels and suppressed IL-1beta release in MSU crystals-treated THP-1 macrophages and BMDMs. | NAD | CD38 antigen | Mus musculus |
| 4 | In conclusion, the present study revealed that MSU crystals could activate CD38 with the ensuing intracellular NAD+ decline to promote inflammatory responses in THP-1 macrophages and BMDMs, while CD38 inhibition could suppress MSU crystals-triggered inflammatory responses, indicating that CD38 is a potential therapeutic target for gout. | NAD | CD38 antigen | Mus musculus |
| 5 | In conclusion, the present study revealed that MSU crystals could activate CD38 with the ensuing intracellular NAD+ decline to promote inflammatory responses in THP-1 macrophages and BMDMs, while CD38 inhibition could suppress MSU crystals-triggered inflammatory responses, indicating that CD38 is a potential therapeutic target for gout. | NAD | CD38 antigen | Mus musculus |