Title : NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.

Pub. Date : 2021 Nov

PMID : 34636169






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Both NUDT15 variant genotype and NT5C2 and PRPS1 mutations were significantly associated with DNA-incorporated thioguanine levels after exposure to thioguanine at therapeutic concentration. Thioguanine nudix hydrolase 15 Homo sapiens
2 Both NUDT15 variant genotype and NT5C2 and PRPS1 mutations were significantly associated with DNA-incorporated thioguanine levels after exposure to thioguanine at therapeutic concentration. Thioguanine nudix hydrolase 15 Homo sapiens