Title : Phosphoinositide-3-Kinase/Akt-Endothelial Nitric Oxide Synthase Signaling Pathway Mediates the Neuroprotective Effect of Sevoflurane Postconditioning in a Rat Model of Hemorrhagic Shock and Resuscitation.

Pub. Date : 2022 Jan

PMID : 34634505






2 Functional Relationships(s)
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1 Phosphoinositide-3-kinase/Akt-endothelial nitric oxide synthase signaling pathway mediates the neuroprotective effect of sevoflurane postconditioning in a rat model of hemorrhagic shock and resuscitation. Sevoflurane AKT serine/threonine kinase 1 Rattus norvegicus
2 CONCLUSION: Sevoflurane postconditioning could attenuate brain injury induced by hemorrhagic shock and resuscitation, and this neuroprotective effect may be partly by upregulation of eNOS through PI3K/Akt signaling pathway. Sevoflurane AKT serine/threonine kinase 1 Rattus norvegicus