Title : Exposure to di-(2-ethylhexyl) phthalate reduces secretion of GDNF via interfering with estrogen pathway and downregulating ERK/c-fos signaling pathway in astrocytes.

Pub. Date : 2021 Dec

PMID : 34624416






2 Functional Relationships(s)
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1 MEHP also decreased p300 levels and downregulated the ERK/c-fos signaling pathway in primary astrocytes. mono-(2-ethylhexyl)phthalate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Honokiol restored GDNF levels following MEHP exposure by activating the ERK/c-fos signaling pathway, while the inhibitor U0126 further reduced the GDNF levels. mono-(2-ethylhexyl)phthalate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus