Title : Effects of dexmedetomidine on postoperative cognitive function of sleep deprivation rats based on changes in inflammatory response.

Pub. Date : 2021 Dec

PMID : 34622713






1 Functional Relationships(s)
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1 Compared with SD group, the escape latency was shortened, original platform-crossing times increased, MDA content declined, SOD activity rose, neurons were arranged orderly and number of Nissl bodies increased in the hippocampal CA1 region, levels of IL-1beta, TNF-alpha, and IL-6 in the hippocampus decreased, Rac1/AKT/NF-kappaB expressions were down-regulated, and proportion of NF-kappaB entering the nucleus declined in SD+DEX group (P < 0.05). Dexmedetomidine tumor necrosis factor Rattus norvegicus