Title : Viral polymerase binding and broad-spectrum antiviral activity of molnupiravir against human seasonal coronaviruses.

Pub. Date : 2021 Dec

PMID : 34619630






2 Functional Relationships(s)
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1 Molnupiravir is a promising pipeline antiviral drug for treating SARS-CoV-2 infection potentially by targeting RNA-dependent RNA polymerase (RdRp). EIDD 2801 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2
2 Molecular docking revealed that the active form of molnupiravir, beta-D-N4-hydroxycytidine (NHC), has similar binding affinity to RdRp of SARS-CoV-2 and seasonal HCoV-NL63, HCoV-OC43 and HCoV-229E. EIDD 2801 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2