Title : CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice.

Pub. Date : 2021 Nov

PMID : 34612580






2 Functional Relationships(s)
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1 Here, we demonstrate that the phosphorylation of WRN by CDK2 on serine residue 426 is critical for WRN to make its DSB repair pathway choice between NHEJ and HR. Serine cyclin dependent kinase 2 Homo sapiens
2 The CDK2 phosphorylation on serine 426 stabilizes WRN"s affinity for RPA, likely increasing its long-range resection at the end of DNA strands, which is a crucial step for HR. Serine cyclin dependent kinase 2 Homo sapiens