Title : Constructing a passive targeting and long retention therapeutic nanoplatform based on water-soluble, non-toxic and highly-stable core-shell poly(amino acid) nanocomplexes.

Pub. Date : 2021 Oct 26

PMID : 34590101






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The Gef-PY NCs have good water-solubility, non-toxicity (correspond to 1/10 dosage of effective gefitinib (hydrochloride) (Gef HCl) (normal drug administration and slow-release) and high stability (120 days, 80% drug retention at 4 or 25 C). Water Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens
2 Such excellent properties (e.g., water-solubility, non-toxicity, high stability, kidney targeting and long retention) of Gef-PY NCs create their prominent anti-fibrosis capabilities, such as decreasing approximately 40% tubulointerstitial fibrosis area and 68% expression of collagen I within 7 days. Water Rho/Rac guanine nucleotide exchange factor 2 Homo sapiens