Pub. Date : 2021 Dec 17
PMID : 34589581
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting EGFR sensitizes 5-Fu-resistant colon cancer cells through modification of the lncRNA-FGD5-AS1-miR-330-3p-Hexokinase 2 axis. | Fluorouracil | epidermal growth factor receptor | Homo sapiens |
| 2 | Here we report that EGFR and lncRNA-FGD5-AS1 promoted 5-Fu resistance of CRC. | Fluorouracil | epidermal growth factor receptor | Homo sapiens |
| 3 | By establishing the 5-Fu-resistant CRC cell line, we detected that EGFR, FGD5-AS1, and glucose metabolism were significantly elevated in 5-Fu-resistant CRC cells. | Fluorouracil | epidermal growth factor receptor | Homo sapiens |
| 4 | By establishing the 5-Fu-resistant CRC cell line, we detected that EGFR, FGD5-AS1, and glucose metabolism were significantly elevated in 5-Fu-resistant CRC cells. | Fluorouracil | epidermal growth factor receptor | Homo sapiens |
| 5 | Finally, in vitro and in vivo xenograft experiments consistently demonstrated that inhibition of EGFR by the specific inhibitor erlotinib effectively enhanced the anti-tumor toxicity of 5-Fu by targeting the EGFR-FGD5-AS1-miR-330-3p-HK2 pathway. | Fluorouracil | epidermal growth factor receptor | Homo sapiens |
| 6 | Finally, in vitro and in vivo xenograft experiments consistently demonstrated that inhibition of EGFR by the specific inhibitor erlotinib effectively enhanced the anti-tumor toxicity of 5-Fu by targeting the EGFR-FGD5-AS1-miR-330-3p-HK2 pathway. | Fluorouracil | epidermal growth factor receptor | Homo sapiens |
| 7 | In summary, this study demonstrates new mechanisms of the EGFR-modulated 5-Fu resistance through modulating the noncoding RNA network, contributing to development of new approaches against chemoresistant CRC. | Fluorouracil | epidermal growth factor receptor | Homo sapiens |