Title : Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway.

Pub. Date : 2021 Nov 28

PMID : 34584036






3 Functional Relationships(s)
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1 The Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting the Wnt/beta-catenin Pathway. ursolic acid catenin beta 1 Homo sapiens
2 We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular beta-catenin, c-myc, and cyclin D1 levels. ursolic acid catenin beta 1 Homo sapiens
3 These findings suggest that MRBE and its active ingredient, ursolic acid, exert antiproliferative activity by promoting the degradation of beta-catenin and may have significant chemopreventive potential against MM. ursolic acid catenin beta 1 Homo sapiens