Title : In Vivo Expansion of Antigen-Specific Regulatory T Cells through Staggered Fc.IL-2 Mutein Dosing and Antigen-Specific Immunotherapy.

Pub. Date : 2021 Sep 28

PMID : 34583939






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Repeated weekly cycles of IL-2 mutein doses (day 0) followed by ASI (day 3) resulted in a 3- to 5-fold enrichment in Treg among Ag-responsive CD4 T cells. treg CD4 antigen Mus musculus
2 Combining Treg enrichment with ASI has the potential to durably treat autoimmune disease or allergy by increasing the Treg/conventional CD4 T cell ratio among autoantigen- or allergen-specific T cells. treg CD4 antigen Mus musculus