Pub. Date : 2022 Jan
PMID : 34582038
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 2 | Thiopurine-S-methyltransferase (TPMT) and nudix hydrolase-15 (NUDT15) are enzymes involved in azathioprine metabolism; variants in the genes encoding these enzymes increase the risk for azathioprine myelotoxicity. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 3 | Thiopurine-S-methyltransferase (TPMT) and nudix hydrolase-15 (NUDT15) are enzymes involved in azathioprine metabolism; variants in the genes encoding these enzymes increase the risk for azathioprine myelotoxicity. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 4 | Thiopurine-S-methyltransferase (TPMT) and nudix hydrolase-15 (NUDT15) are enzymes involved in azathioprine metabolism; variants in the genes encoding these enzymes increase the risk for azathioprine myelotoxicity. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 5 | Thiopurine-S-methyltransferase (TPMT) and nudix hydrolase-15 (NUDT15) are enzymes involved in azathioprine metabolism; variants in the genes encoding these enzymes increase the risk for azathioprine myelotoxicity. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 6 | We hypothesized that in patients with inflammatory diseases, TPMT and NUDT15 genotype data predict the risk of discontinuing azathioprine due to myelotoxicity. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 7 | In conclusion, TPMT and NUDT15 metabolizer status predicts discontinuation due to myelotoxicity for patients taking azathioprine for inflammatory conditions. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |