Protein Name thiopurine S-methyltransferase
Organism Homo sapiens
Gene ID 7172
Gene Symbol

TPMT

UniProt P51580 (TPMT_HUMAN), A0A024QZW0 (A0A024QZW0_HUMAN)
Relationships Total Number of functionally related compound(s) : 179
Total Number of Articles : 772
Description

thiopurine S-methyltransferase

Gene Summary

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

synonyms
  • thiopurine S-methyltransferase
  • S-adenosyl-L-methionine:thiopurine S-methyltransferase
  • TPMTD
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Properties