Title : Synergistic Interactions of Cannabidiol with Chemotherapeutic Drugs in MCF7 Cells: Mode of Interaction and Proteomics Analysis of Mechanisms.

Pub. Date : 2021 Sep 18

PMID : 34576262






2 Functional Relationships(s)
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1 We reported the inhibition of topoisomerase II beta and alpha, cullin 1, V-type proton ATPase, and CDK-6 in CBD-treated MCF7 cells for the first time as additional cytotoxic mechanisms of CBD, alongside sabotaged energy production and reduced mitochondrial translation. Cannabidiol cyclin dependent kinase 6 Homo sapiens
2 We reported the inhibition of topoisomerase II beta and alpha, cullin 1, V-type proton ATPase, and CDK-6 in CBD-treated MCF7 cells for the first time as additional cytotoxic mechanisms of CBD, alongside sabotaged energy production and reduced mitochondrial translation. Cannabidiol cyclin dependent kinase 6 Homo sapiens