Protein Name cyclin dependent kinase 6
Organism Homo sapiens
Gene ID 1021
Gene Symbol


UniProt Q00534 (CDK6_HUMAN)
Relationships Total Number of functionally related compound(s) : 324
Total Number of Articles : 394

cyclin dependent kinase 6

Gene Summary

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

  • cyclin-dependent kinase 6
  • cell division protein kinase 6
  • serine/threonine-protein kinase PLSTIRE
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