Title : p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.

Pub. Date : 2021 Aug 26

PMID : 34572995






1 Functional Relationships(s)
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1 In WT hearts, AngII infusion increased significantly the levels of superoxide production, the expressions of Nox subunits, the expression of PKCalpha and C-Src and the activation of ASK1 (apoptosis signal-regulating kinase 1), MKK3/6, ERK1/2, p38 MAPK and JNK signalling pathways together with an elevated expression of apoptotic markers, i.e., gammaH2AX and p53 in the cardiomyocytes. Superoxides angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus