Title : Preclinical Studies on the Effect of Rucaparib in Ovarian Cancer: Impact of BRCA2 Status.

Pub. Date : 2021 Sep 15

PMID : 34572083






2 Functional Relationships(s)
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1 The migratory and proliferative capacity of PEO1 cells was compromised following treatment with rucaparib 10 microM compared to BRCA2 wild-type cell lines via a mechanism involving the mTOR pathway. rucaparib twinkle mtDNA helicase Homo sapiens
2 Rucaparib treatment significantly increased DNA damage primarily in PEO1 cells and SKOV3 cells compared with wild type. rucaparib twinkle mtDNA helicase Homo sapiens