Pub. Date : 2021
PMID : 34567221
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Idebenone-Activating Autophagic Degradation of alpha-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson"s Disease: A Network Pharmacological Approach. | idebenone | synuclein alpha | Homo sapiens |
| 2 | In the cell model of PD, Idebenone activated autophagy and promoted alpha-synuclein degradation by suppressing the AKT/mTOR pathway. | idebenone | synuclein alpha | Homo sapiens |
| 3 | Pretreating cells with chloroquine (CQ) to block autophagic flux could diminish the pharmacological effect of Idebenone to clear alpha-synuclein. | idebenone | synuclein alpha | Homo sapiens |
| 4 | Conclusion: This study demonstrated that Idebenone exerts its anti-PD effects by enhancing autophagy and clearance of alpha-synuclein, thus providing a theoretical and experimental basis for Idebenone therapy against PD. | idebenone | synuclein alpha | Homo sapiens |
| 5 | Conclusion: This study demonstrated that Idebenone exerts its anti-PD effects by enhancing autophagy and clearance of alpha-synuclein, thus providing a theoretical and experimental basis for Idebenone therapy against PD. | idebenone | synuclein alpha | Homo sapiens |