Title : Ultramicronized Palmitoylethanolamide Inhibits NLRP3 Inflammasome Expression and Pro-Inflammatory Response Activated by SARS-CoV-2 Spike Protein in Cultured Murine Alveolar Macrophages.

Pub. Date : 2021 Sep 2

PMID : 34564408






1 Functional Relationships(s)
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1 SP challenge caused a significant concentration-dependent increase in proinflammatory markers (TLR4, p-p38 MAPK, NF-kappaB) paralleled to a marked upregulation of inflammasome-dependent inflammatory pathways (NLRP3, Caspase-1) with IL-6, IL-1beta, TNF-alpha over-release, compared to vehicle group. sp nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus