Title : Saringosterol from Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient Mice.

Pub. Date : 2021 Aug 26

PMID : 34564147






3 Functional Relationships(s)
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1 Liver X receptor (LXR) alpha and beta are transcription factors belonging to the nuclear receptor superfamily, which play important roles in cholesterol homeostasis. Cholesterol nuclear receptor subfamily 1, group H, member 3 Mus musculus
2 Meanwhile, reduced serum levels of cholesterol, accompanied by altered expression of LXR-regulated genes involved in cholesterol absorption, transport, efflux, excretion, and elimination, were observed in apoE-knockout mice after saringosterol treatment. Cholesterol nuclear receptor subfamily 1, group H, member 3 Mus musculus
3 Meanwhile, reduced serum levels of cholesterol, accompanied by altered expression of LXR-regulated genes involved in cholesterol absorption, transport, efflux, excretion, and elimination, were observed in apoE-knockout mice after saringosterol treatment. Cholesterol nuclear receptor subfamily 1, group H, member 3 Mus musculus