Title : Discovery of ancestral L-ornithine and L-lysine decarboxylases reveals parallel, pseudoconvergent evolution of polyamine biosynthesis.

Pub. Date : 2021 Oct

PMID : 34560100






1 Functional Relationships(s)
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1 The polyamines putrescine, agmatine and cadaverine, are produced by pyridoxal 5"-phosphate-dependent L-ornithine, L-arginine and L-lysine decarboxylases (ODC, ADC, LDC), respectively, from both the alanine racemase (AR) and aspartate aminotransferase (AAT) folds. Pyridoxal Phosphate ornithine decarboxylase 1 Homo sapiens