Title : Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma.

Pub. Date : 2022 Feb

PMID : 34551970






1 Functional Relationships(s)
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1 Vandetanib, an inhibitor of VEGFR/RET/EGFR, was found to target ACVR1 (Kd=150nM) and reduce DIPG cell viability in vitro, but has limited ability to cross the blood-brain-barrier. vandetanib kinase insert domain receptor Homo sapiens