Title : [Endoplasmic reticulum stress in hepatic stellate cells induced by tunicamycin promotes apoptosis and cell cycle arrest].

Pub. Date : 2021 Sep

PMID : 34533126






1 Functional Relationships(s)
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1 Compared with the control group and treatment group with DMSO, the treatment group with 1 mug/mL of tunicamycin had no significant change in cell proliferation, but the expression of alpha-SMA was up-regulated with the apoptosis increased, the proportion of G1 phase cells was significantly increased and that of S phase cells decreased, the ERS induced apoptosis related signal proteins CHOP and caspase-12 were significantly up-regulated, and the expression of cyclin D1 was significantly down-regulated. Tunicamycin caspase 12 Rattus norvegicus