Title : NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway.

Pub. Date : 2021 Sep 16

PMID : 34530866






2 Functional Relationships(s)
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1 Results of mechanistic pathway analysis indicated that the detrimental effects of CCH might be associated with decreased gene expression of PPAR-gamma co-activator1alpha (PGC-1alpha) and its upstream transcription factor Sirt1, while NAD+ treatment markedly reversed their decrease. 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine sirtuin 1 Rattus norvegicus
2 CONCLUSIONS: NAD+ ameliorated cognitive impairment and dampened neuroinflammation in CCH models in vivo and in vitro, and these beneficial effects were associated with mitochondrial protection and ROS inhibition via activating Sirt1/PGC-1alpha pathway. 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine sirtuin 1 Rattus norvegicus