Title : SIRT6 silencing overcomes resistance to sorafenib by promoting ferroptosis in gastric cancer.

Pub. Date : 2021 Nov 5

PMID : 34530350






2 Functional Relationships(s)
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1 The overexpression of GPX4 or activation of Keap1/Nrf2 reverses the effects of the downregulation of SIRT6 on sorafenib-induced ferroptosis. Sorafenib glutathione peroxidase 4 Homo sapiens
2 Thus, targeting the SIRT6/Keap1/Nrf2/GPX4 signalling pathway may be a potential strategy for overcoming sorafenib resistance in GC. Sorafenib glutathione peroxidase 4 Homo sapiens