Protein Name glutathione peroxidase 4
Organism Homo sapiens
Gene ID 2879
Gene Symbol


UniProt P36969 (GPX4_HUMAN), Q6PI42 (Q6PI42_HUMAN)
Relationships Total Number of functionally related compound(s) : 402
Total Number of Articles : 544

glutathione peroxidase 4

Gene Summary

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018]

  • phospholipid hydroperoxide glutathione peroxidase GPX4
  • epididymis secretory sperm binding protein
  • phospholipid hydroperoxidase
Click to show/hide the synonyms