Title : Effects of CPY3A5 Genetic Polymorphisms on the Pharmacokinetics of Extendedrelease and Immediate-release Tacrolimus Formulations in Renal Transplant Recipients: A Systematic Review and Meta-analysis.

Pub. Date : 2021

PMID : 34525930






1 Functional Relationships(s)
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1 BACKGROUND: Although the pharmacokinetic variability of Tacrolimus (Tac) metabolism is primarily influenced by CYP3A5 genotypes, the potential effect according to CYP3A5 polymorphisms in Tac extended-release (Tac-ER) and immediate-release (Tac-IR) and between these formulations" conversion needs further investigation. Tacrolimus cytochrome P450 family 3 subfamily A member 5 Homo sapiens