Title : Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2.

Pub. Date : 2021 Nov 3

PMID : 34506725






1 Functional Relationships(s)
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1 Thus, our study reveals an oligodendrocyte-to-axon delivery of SIRT2, which enhances ATP production by deacetylating mitochondrial proteins, providing a target for boosting axonal bioenergetic metabolism in neurological disorders. Adenosine Triphosphate sirtuin 2 Mus musculus