Title : Pathogenic DPYD Variants and Treatment-Related Mortality in Patients Receiving Fluoropyrimidine Chemotherapy: A Systematic Review and Meta-Analysis.

Pub. Date : 2021 Dec

PMID : 34506675






1 Functional Relationships(s)
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1 IMPLICATIONS FOR PRACTICE: The syndrome of dihydropyrimidine deaminase (DPD) deficiency is an uncommon but well-described cause of severe toxicity related to fluoropyrimidine chemotherapy agents (5-fluorouracil and capecitabine). dihydropyrimidine dihydropyrimidine dehydrogenase Homo sapiens