Title : ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo.

Pub. Date : 2021 Aug 24

PMID : 34500564






2 Functional Relationships(s)
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1 S1P1 modulators, such as fingolimod, disrupt this recycling by inducing persistent S1P1 internalization and receptor degradation, which results in blocked egress of T cells from the secondary lymphoid tissues. Fingolimod Hydrochloride sphingosine-1-phosphate receptor 1 Mus musculus
2 S1P1 modulators, such as fingolimod, disrupt this recycling by inducing persistent S1P1 internalization and receptor degradation, which results in blocked egress of T cells from the secondary lymphoid tissues. Fingolimod Hydrochloride sphingosine-1-phosphate receptor 1 Mus musculus