Protein Name sphingosine-1-phosphate receptor 1
Organism Mus musculus
Gene ID 13609
Gene Symbol


UniProt O08530 (S1PR1_MOUSE)
Relationships Total Number of functionally related compound(s) : 371
Total Number of Articles : 640

sphingosine-1-phosphate receptor 1

Gene Summary

This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]

  • sphingosine 1-phosphate receptor 1
  • S1P receptor 1
  • S1P receptor Edg-1
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