| Protein Name | sphingosine-1-phosphate receptor 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 13609 |
| Gene Symbol | S1pr1 |
| UniProt | O08530 (S1PR1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
371
Total Number of Articles : 640 |
Description |
sphingosine-1-phosphate receptor 1 |
| Gene Summary |
This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010] |
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