Title : Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation.

Pub. Date : 2021 Nov 1

PMID : 34499618






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Active PKN2 promoted phosphorylation of human eNOS at serine 1177 and at a newly identified site, serine 1179. Serine nitric oxide synthase 3 Homo sapiens
2 PKN2-mediated eNOS phosphorylation at serine 1177 involved phosphorylation of AKT synergistically with mTORC2-mediated AKT phosphorylation while active PKN2 directly phosphorylated human eNOS at serine 1179. Serine nitric oxide synthase 3 Homo sapiens
3 PKN2-mediated eNOS phosphorylation at serine 1177 involved phosphorylation of AKT synergistically with mTORC2-mediated AKT phosphorylation while active PKN2 directly phosphorylated human eNOS at serine 1179. Serine nitric oxide synthase 3 Homo sapiens
4 PKN2-mediated eNOS phosphorylation at serine 1177 involved phosphorylation of AKT synergistically with mTORC2-mediated AKT phosphorylation while active PKN2 directly phosphorylated human eNOS at serine 1179. Serine nitric oxide synthase 3 Homo sapiens