Pub. Date : 2021 Oct 31
PMID : 34494876
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2. | Nitrogen | angiotensin converting enzyme 2 | Homo sapiens |
| 2 | However, the contribution of N-glycosylation to ACE2 function is poorly understood. | Nitrogen | angiotensin converting enzyme 2 | Homo sapiens |
| 3 | The elimination of N-glycosylation by tunicamycin (TM) treatment, or mutagenesis, showed that N-glycosylation is critical for the proper cell surface expression of ACE2 but not for its carboxiprotease activity. | Nitrogen | angiotensin converting enzyme 2 | Homo sapiens |
| 4 | The elimination of N-glycosylation by tunicamycin (TM) treatment, or mutagenesis, showed that N-glycosylation is critical for the proper cell surface expression of ACE2 but not for its carboxiprotease activity. | Nitrogen | angiotensin converting enzyme 2 | Homo sapiens |
| 5 | Impairment of hACE2 N-glycosylation decreased cell-to-cell fusion mediated by SARS-CoV S protein but not that mediated by SARS-CoV-2 S protein. | Nitrogen | angiotensin converting enzyme 2 | Homo sapiens |
| 6 | Finally, we found that hACE2 N-glycosylation is required for an efficient viral entry of SARS-CoV/SARS-CoV-2 S pseudotyped viruses, which may be the result of low cell surface expression of the deglycosylated ACE2 receptor. | Nitrogen | angiotensin converting enzyme 2 | Homo sapiens |