Title : Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2.

Pub. Date : 2021

PMID : 34483914






1 Functional Relationships(s)
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1 Remdesivir, a prodrug targeting RNA-dependent-RNA-polymerase, and cyclosporine, a calcineurin inhibitor, individually exerted inhibitory activity against human coronavirus OC43 (HCoV-OC43) in HCT-8 and MRC-5 cells at EC50 values of 96 +- 34 ~ 85 +- 23 nM and 2,920 +- 364 ~ 4,419 +- 490 nM, respectively. Cyclosporine calcineurin binding protein 1 Homo sapiens