Title : IL-1β induces changes in expression of core circadian clock components PER2 and BMAL1 in primary human chondrocytes through the NMDA receptor/CREB and NF-κB signalling pathways.

Pub. Date : 2021 Nov

PMID : 34481895






1 Functional Relationships(s)
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1 We found IL-1beta treatment of primary human chondrocytes led to activation of NMDA receptors as evidenced by an increase in phosphorylation of GluN1 and an increase in intracellular calcium which was blocked by the NMDAR antagonist MK801. Calcium interleukin 1 alpha Homo sapiens